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. 2020 Mar 14;117(3):890–902. doi: 10.1093/cvr/cvaa067

Figure 2.

Figure 2

Sectm1a deficiency aggravates LPS-induced systemic inflammation and mortality. (A) Products of qRT-PCR were run on agarose gel to validate that Sectm1a KO model was successfully generated. (B) WT and Sectm1a KO mice injected i.p. with LPS (10 mg/kg) were monitored for survival up to 72 h post-treatment. n = 10–20. (C–E) Plasma cytokine levels (C: IL-6; D: TNFα; E: IL-1β) of WT and Sectm1a KO mice were measured with ELISA 12 h after LPS injection (number of serum samples: n = 9–12 for C; n = 7 for D; n = 6–10 for E) (*P < 0.05; data are presented as mean ± SEM; Student’s t-test).