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. 2020 Mar 14;117(3):890–902. doi: 10.1093/cvr/cvaa067

Figure 3.

Figure 3

Sectm1a deficiency enhances cardiac inflammation and dysfunction. 12 h after injecting mice with LPS (10 mg/kg) (A and B) cardiac function was determined by echocardiography (n = 5–9). (C–J) Representative flow cytometry plots and quantification of cardiac macrophage marker expression showed more macrophage accumulation (F4/80+) with inflammatory phenotype (CCR2+, MHC-II+, CD206-) in the heart of KO mice 12 h after LPS injection (n = 4). Gating strategy is shown in Supplementary material online, Figure S3A. (K–M) cytokine levels in the myocardium were measured by ELISA (n = 3–4) (*P < 0.05; data are presented as mean ± SEM; Student’s t-test).