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Macrophage origins in developing heart valves. The sources of macrophages in the cardiovascular system during development include the yolk sac and AGM region in embryos, the foetal liver in foetuses and newborns, and the bone marrow during definitive haematopoiesis after birth.25 The right panel shows a mouse aortic valve at 1 month-of-age with CD45+ cells stained red that are predominantly heterogeneous macrophages.10
