TABLE 1.
Characteristics | All (n = 67) | Pediatric (n = 43) | Adult (n = 24) | P Value |
---|---|---|---|---|
Male/female | 31/36 | 19/24 | 12/12 | 0.65 |
Age at LT, years | 2.1 (0.9‐45.2) | 1.2 (0.6‐2.0) | 54.8 (31.5‐61.1) | <0.001 |
Age at PTLDs, years | 6.1 (1.9‐53.4) | 2.8 (1.6‐4.2) | 60.0 (38.6‐66.3) | <0.001 |
BA/metabolic/ALF/HCV/others | 38/5/6/8/10 | 35/3/2/0/3 | 3/2/4/8/7 | <0.001 |
Malignant/benign liver etiology | 7/60 | 1/42 | 6/18 | 0.004 |
ABO incompatible/not | 11/56 | 9/34 | 2/18 | 0.26 |
EBV serology: +/− at LT | 39/10 | 19/10 | 20/0 | <0.001 |
CMV serology: +/− at LT | 37/11 | 20/9 | 17/2 | 0.09 |
EBV PCR: +/− | 31/9 | 25/1 | 6/8 | <0.001 |
EBER: +/− | 35/24 | 30/9 | 5/15 | <0.001 |
PS: 0/1/2/3/4 | 2/46/13/4/2 | 0/28/10/4/1 | 2/18/3/0/1 | 0.06 |
Ann Arbor stage: I/II/III/IV | 35/9/10/12 | 22/4/8/8 | 13/5/2/4 | 0.44 |
Bulky tumor (>5 cm)/not | 7/58 | 3/38 | 4/20 | 0.25 |
Extranodal lesion ≥ 1/not | 28/39 | 13/30 | 15/9 | 0.01 |
LDH at PTLD, U/L | 372 (258‐524) | 375 (262‐525) | 346 (244‐523) | 0.70 |
sIL2R at PTLD, U/mL | 2480 (1605‐4225) | 2660 (1433‐4390) | 2420 (1710‐4150) | 0.96 |
IPI: 0/1/2/3/4/5 | 7/21/16/8/5 | 5/13/9/5/2 | 2/8/7/3/3 | 0.85 |
Tacrolimus/cyclosporine | 57/2 | 36/0 | 21/2 | 0.049 |
Monomorphic (DLBCL/Burkitt)/polymorphic/nondestructive (PH/infectious mononucleosis/FFH)/PTLD‐like | 24 (13/7)/5/21 (5/14/2)/17 | 12 (6/4)/2/20 (5/13/2)/9 | 12 (7/3)/3/1 (0/1/0)/8 | 0.005 |
Chemotherapy/not | 23/39 | 11/28 | 12/11 | 0.16 |
The data are presented as median (interquartile range) for continuous variables and number for categorical variables. P values < 0.05 are bold.