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. 2021 Sep 16;14:1169–1184. doi: 10.2147/PGPM.S323379

Table 2.

Positive Biological Processes Only Enriched in ICM Patients with Gene Set Enrichment Analysis (GSEA)

GO: Biological Process Enriched in ICM Compared with DCM Only Significant in ICM
GS NES p GS NES p
Cell proliferation and differentiation
Positive regulation of cell population proliferation 27 1.753 0.000 29 1.338 0.087 Yes
Regulation of cell population proliferation 46 1.565 0.013 51 0.998 0.487 Yes
Negative regulation of cell population proliferation 21 1.548 0.046 25 0.664 0.904 Yes
Regulation of MAPK cascade 29 1.712 0.005 30 0.803 0.756 Yes
Positive regulation of MAPK cascade 25 1.624 0.011 26 0.744 0.816 Yes
Epithelial cell differentiation 26 1.523 0.032 29 0.959 0.548 Yes
Structure organization
Extracellular structure organization 37 1.796 0.003 44 1.281 0.113 Yes
Anatomical structure formation involved in morphogenesis 41 1.479 0.036 47 0.832 0.755 Yes
Tube development 44 1.437 0.042 49 0.958 0.572 Yes
Others
Signal transduction by protein phosphorylation 34 1.473 0.037 37 1.364 0.084 Yes
Biological adhesion 82 1.459 0.018 89 1.147 0.231 Yes

Abbreviations: ICM, ischemic cardiomyopathy; DCM, dilated cardiomyopathy; GO, gene ontology; GS, gene size; NES, normalized enrichment score.