Table 3.
Positive Biological Processes Only Enriched in DCM Patients with Gene Set Enrichment Analysis (GSEA)
| GO: Biological Process | Enriched in DCM | Compared with ICM | Only Significant in DCM | ||||
|---|---|---|---|---|---|---|---|
| GS | NES | p | GS | NES | p | ||
| Metabolic Processes | |||||||
| Organic acid metabolic process | 31 | 1.867 | 0.000 | Not enriched | Yes | ||
| Organic cyclic compound catabolic process | 16 | 1.684 | 0.006 | Not enriched | Yes | ||
| Cellular protein catabolic process | 15 | 1.604 | 0.006 | Not enriched | Yes | ||
| Carbohydrate metabolic process | 15 | 1.602 | 0.013 | Not enriched | Yes | ||
| Small molecule metabolic process | 53 | 1.580 | 0.005 | Not enriched | Yes | ||
| Cellular macromolecule catabolic process | 20 | 1.578 | 0.010 | Not enriched | Yes | ||
| Monocarboxylic acid metabolic process | 19 | 1.548 | 0.030 | Not enriched | Yes | ||
| Regulation of small molecule metabolic process | 21 | 1.534 | 0.024 | Not enriched | Yes | ||
| Small molecule biosynthetic process | 21 | 1.516 | 0.019 | Not enriched | Yes | ||
| Carbohydrate derivative metabolic process | 21 | 1.436 | 0.048 | Not enriched | Yes | ||
| Macromolecule catabolic process | 34 | 1.435 | 0.039 | Not enriched | Yes | ||
| Cell signaling transduction | |||||||
| Cell cell signaling by Wnt | 18 | 1.605 | 0.010 | Not enriched | Yes | ||
| Canonical Wnt signaling pathway | 15 | 1.604 | 0.011 | Not enriched | Yes | ||
| Regulation of Wnt signaling pathway | 15 | 1.562 | 0.013 | Not enriched | Yes | ||
| Cell surface receptor signaling pathway involved in cell-cell signaling | 21 | 1.558 | 0.023 | Not enriched | Yes | ||
| Response to tumor necrosis factor | 19 | 1.552 | 0.013 | Not enriched | Yes | ||
| Cytokine mediated signaling pathway | 31 | 1.422 | 0.037 | 24 | 0.536 | 0.988 | Yes |
| Cell cycle | |||||||
| Regulation of cell cycle | 18 | 1.719 | 0.000 | 15 | 0.919 | 0.571 | Yes |
| Cell cycle process | 21 | 1.708 | 0.000 | Not enriched | Yes | ||
| Cell cycle | 24 | 1.631 | 0.008 | 21 | 0.817 | 0.704 | Yes |
| Morphogenesis | |||||||
| Morphogenesis of an epithelium | 16 | 1.634 | 0.011 | 17 | 0.556 | 0.979 | Yes |
| Animal organ morphogenesis | 36 | 1.435 | 0.039 | 31 | 1.336 | 0.095 | Yes |
| Tissue morphogenesis | 24 | 1.476 | 0.027 | 23 | 0.918 | 0.584 | Yes |
| Others | |||||||
| Oxidation reduction process | 25 | 1.713 | 0.000 | Not enriched | Yes | ||
| Posttranscriptional regulation of gene expression | 15 | 1.688 | 0.005 | Not enriched | Yes | ||
| Regulation of hemopoiesis | 17 | 1.655 | 0.005 | 16 | 1.104 | 0.321 | Yes |
| Transmembrane transport | 34 | 1.545 | 0.010 | 27 | 0.634 | 0.943 | Yes |
| Response to abiotic stimulus | 39 | 1.542 | 0.008 | 29 | 1.056 | 0.391 | Yes |
| Response to oxygen levels | 20 | 1.522 | 0.020 | Not enriched | Yes | ||
| Immune system development | 23 | 1.506 | 0.023 | 21 | 1.083 | 0.333 | Yes |
| Epithelium development | 44 | 1.458 | 0.025 | 39 | 1.211 | 0.189 | Yes |
| Myeloid leukocyte activation | 46 | 1.445 | 0.029 | 38 | 1.321 | 0.096 | Yes |
| Interspecies interaction between organisms | 51 | 1.419 | 0.029 | Not enriched | Yes | ||
| Cell activation involved in immune response | 44 | 1.406 | 0.044 | 37 | 1.221 | 0.189 | Yes |
Abbreviations: ICM, ischemic cardiomyopathy; DCM, dilated cardiomyopathy; GO, gene ontology; GS, gene size; NES, normalized enrichment score.