TABLE 1.

Whole‐genome sequenced participants

	Overall	BioFIND	HBS	PDBP	PPMI
Total, n	3941	172	867	1469	1433
Sex and age
Female, n (%)	1725 (43.8)	71 (41.3)	372 (42.9)	640 (43.6)	642 (44.8)
Age at baseline (years), mean (SD)	63.5 (10.7)	67.1 (6.9)	66.1 (10.1)	64.0 (10.0)	61.1 (11.7)
Self‐reported race
White, n (%)	3726 (94.6)	161 (93.6)	844 (97.3)	1397 (95.1)	1324 (92.5)
Mixed ancestry, n (%)	65 (1.6)	2 (1.2)	2 (0.2)	6 (0.4)	55 (3.8)
Black or African American, n (%)	63 (1.6)	3 (1.7)	10 (1.2)	32 (2.2)	18 (1.3)
Asian, n (%)	34 (0.9)	1 (0.6)	7 (0.8)	16 (1.1)	10 (0.7)
Study arms
Parkinson's disease, n (%)	2005 (51.1)	99 (57.6)	640 (73.8)	858 (58.9)	408 (28.5)
Healthy control, n (%)	963 (24.5)	73 (42.4)	227 (26.2)	470 (32.3)	193 (13.5)
Genetic cohort PD, n (%)	179 (4.6)				179 (12.5)
Genetic cohort unaffected, n (%)	222 (5.7)				222 (15.5)
Genetic registry PD, n (%)	125 (3.2)				125 (8.7)
Genetic registry unaffected, n (%)	179 (4.6)				179 (12.5)
Prodromal, n (%)	64 (1.6)				64 (4.5)
SWEDD, n (%)	62 (1.6)				62 (4.3)
Disease control, n (%)	127 (3.2)			127 (8.7)
Variant metrics
MEAN_COVERAGE, median (Q1, Q3)	33.9 (31.2, 36.2)	35.0 (34.1, 35.7)	33.4 (30.7, 36.3)	33.3 (30.8, 36.3)	34.2 (31.8, 36.4)
MEDIAN_COVERAGE, median (Q1, Q3)	34.0 (32.0, 37.0)	35.0 (35.0, 36.0)	34.0 (31.0, 37.0)	34.0 (31.0, 37.0)	35.0 (32.0, 37.0)
READS/K, median (Q1, Q3)	3519 (3254, 3760)	3629 (3552, 3690)	3489 (3198, 3765)	3446 (3194, 3742)	3565 (3322, 3789)
AVG_DP, median (Q1, Q3)	35.2 (32.6, 37.6)	36.3 (35.5, 36.9)	34.9 (32.0, 37.7)	34.5 (31.9, 37.4)	35.7 (33.2, 37.9)
FREEMIX, median (Q1, Q3)	0.0 (0.0, 0.0)	0.0 (0.0, 0.0)	0.0 (0.0, 0.0)	0.0 (0.0, 0.0)	0.0 (0.0, 0.0)

AVG_DP, average depth; PD, Parkinson's disease; SWEDD, scan without evidence of dopamine deficit.