FIGURE 1.
l‐cysteine and NaHS cause a further increase in tension of phenylephrine (PE)‐contracted mouse aortic rings. Representative traces of concentration–response curves induced by (a) l‐cysteine (10–300 nM), (b) NaHS (10–300 nM) or (c) vehicle (H2O) on a stable tone of PE (1 μM). The increase in contraction was blunted by the mechanical endothelium removal for both (d) l‐cysteine (n = 10 mice) and (e) NaHS (n = 7 mice). Values shown are means ± SEM and expressed as δ increase in tension over PE contraction (dyne/mg tissue). *P < 0.05 significantly different as indicated; two‐way ANOVA with Bonferroni's post hoc test