FIGURE 7.

Carotid arteries of CSE^−/− mice display a generalized hyporeactivity to different agonists. Cumulative concentration–response curves performed with (a) phenylephrine (PE; 1 nM to 3 μM; n = 7 WT and n = 8 CSE^−/− mice), (b) 5‐HT (1 nM to 3 μM; n = 5 WT and n = 9 CSE^−/− mice), (c) U46619 (1 nM to 0.3 μM; n = 5 WT and n = 8 CSE^−/− mice) were significantly reducted in CSE^−/− mice compared to WT mice. Values shown are means ± SEM and are expressed as contraction (dyne·mg^‐1 tissue). *P < 0.05 significantly different compared to WT mice; two‐way ANOVA with Bonferroni's post hoc test