FIGURE 10.

Inosine 3′,5′‐cyclic monophosphate (cIMP) butyrate causes an increase in tension in phenylephrine (PE)‐contracted mouse aortic rings. (a) Chemical structure of cIMP butyrate, (b) representative trace of concentration–response curves induced by cIMP butyrate (0.1 nM to 1 μM) on basal tone, (c) cIMP butyrate (0.1 nM to 1 μM, n = 8 mice) causes an increase in contraction on PE stable tone (n = 10 mice). Values shown are means ± SEM and expressed as δ increase in tension over PE contraction (dyne/mg tissue). *P < 0.05 significantly different as indicated; two‐way ANOVA with Bonferroni's post hoc test