Table 1.

Crystallographic structures analysed for conformational changes, co‐crystallized with peptides or peptide inhibitors. NS3_PRO refers to the protease domain of the NS3 protein, ignoring the helicase part of the protein, while NS2B_CF refers only to the hydrophilic loop of NS2B, which acts as a cofactor for the NS3_PRO activation.

Virus	PDB ID	Structural Information	Resolution (Å)
DENV‐1	3L6P[a]	NS2BCF‐GlyL‐NS3PROΔ10	2.20
DENV‐2	2FOM	NS2BCF‐GlyL‐NS3PRO	1.50
DENV‐3	3U1I[b]	NS2BCF‐NS3PRO+NDL	2.30
DENV‐3	3U1J	NS2BCF‐NS3PRO+Aprotinin	1.80
DENV‐4	2WHX[c]	NS2B18‐GlyL‐NS3full	2.20
DENV‐4	2VBC[c]	NS2B18‐GlyL‐NS3full	3.15
WNV	2FP7	NS2BCF‐GlyL‐NS3PRO+NDL	1.68
WNV	2IJO	NS2BCF‐GlyL‐NS3PRO+BPTI	2.30
WNV	3E90	NS2BCF‐GlyL‐NS3PRO+NKK	2.45

[a] The construct has a 10 residues deletion in the N‐terminus of NS3_PRO, to facilitate crystallization. [c] Missing NS3 Pro10‐Ala16. [b] Instead of using the full hydrophilic loop from NS2B, a short sequence of 18 residues was used; this was done only to provide solubility to the expressed complex. NDL: Bz‐Nle‐Lys‐Arg‐Arg‐H, BPTI: bovine pancreatic trypsin inhibitor, NKK: Naph‐Lys‐Lys‐Arg‐H, DENV: dengue virus, WNV: West Nile virus Bz‐benzyl, Nle‐norleucine, Naph‐naphthalene