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. 2021 Sep 20;19:281. doi: 10.1186/s12951-021-01035-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Comparison of the cytotoxic effect and anti-inflammatory effect of NCs to RAW264.7, including DL-DHLA-AuNCs, R-DHLA-AuNCs, DL-DHLA-AuNCs-Zn, and R-DHLA-AuNCs-Zn: a RAW264.7 cells. b The western blot analysis (b) and semiquantitative analysis of IL-1β (c) and TNF-α (d) *P < 0.05;**P < 0.01;***P < 0.001; Data presented as mean ± SD. (n = 6 /group); Con indicated the culture of only RAW264.7 cells after 24 h; LPS represented the RAW264.7 cells were tested by LPS-stimulation after 24 h; Others represented RAW264.7 cells were pre-stimulated by LPS and then cultured with various agents after 24 h