Table 2.

Comparison of the motor function recovery after SCI by using different medicines

Nanomedicines	Motor function recovery	Therapeutic effects	Advantages/disadvantages	Refs.
Glutathione	Improve significantly	Antioxidant	Reduces inflammation; very low bioavailability	[29]
Methylprednisolone	Improve significantly	Immunosuppressant	Reduces inflammation; water-sodium retention, susceptible to infection	[6, 30]
Hydralazine	Improve significantly	Antioxidant	Reduces inflammation; short half-life and long-term toxicity	[31]
NT3-Chitosan	Improve significantly	Anti-infection, neuroprotection	Regeneration; difficult to be dissolved in human fluid	[32]
CeO2-PCL	Improve in vitro biocompatibility and auto-recovery abilities	Delivered a bone regeneration drug	Increases biocompatibility of the drug; not available for injection and the in vivo effects are unknown	[33]
Se-CQDs	Improve significantly after 8 weeks	Reduced the inflammation, astrogliosis, and apoptosis induced by secondary injury	Remarkable protective effect for nerves; not cost-effective, toxic concern	[34]
R-DHLA-AuNCs-Zn	Improve significantly after 7 days	Immunosuppressant	Reduces inflammation, anti-apoptosis, anti-oxidant, injectable, low toxicity, cost-effective, simple preparation	Current work

NT3, neurotrophin3; CeO₂-PCL (CeO₂ particles assembled onto poly (∊ -caprolactone) (PCL)) Se-CODS (Selenium-Doped Carbon Quantum Dots)