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. 2021 Sep 20;19:282. doi: 10.1186/s12951-021-01037-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Characterization of the hybrid nanoassemblies. a Schematical illustration of the preparation of DG PEG_2K NPs; b Intensity size distribution profiles, TEM images as well as intuitive photographs of DG NPs, the scale bar represents 100 nm; c Molecular dynamics simulation of DiR and GA molecules in hybrid nanoassembly; d Intensity size distribution profiles, TEM images as well as intuitive photographs of DG PEG_2K NPs, the scale bar represents 100 nm; e Colloidal stability of DG NPs and DG PEG_2K NPs during incubation in PBS (pH = 7.4) (n = 3); (f, g In vitro photothermal efficiency of DiR Sol, DG NPs and DG PEG_2K NPs after incubated in PBS (pH 7.4) for 12 h (n = 3)