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. 2021 Sep 20;19:282. doi: 10.1186/s12951-021-01037-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The pharmacokinetic profile and in vivo photothermal efficiency of DG PEG_2K NPs. a The concentration–time curves of DiR Sol, DG NPs and DG PEG_2K NPs at a DiR equivalent dose of 1 mg kg⁻¹ (n = 6); b Living image of 4T1 tumor-bearing BALB/c mice treated with DiR Sol, DG NPs and DG PEG_2K NPs at a DiR equivalent dose of 1 mg/kg (n = 3), the tumor is indicated by circles; c Ex vivo image of major organs and tumors at the peak point of tumor accumulating (6 h post-injection for DiR Sol and DG NPs and 12 h for DG PEG_2K NPs); d Average fluorescence intensity of c ( n.s. no significance, ****P < 0.0001.); e Thermal imagery of tumor-bearing mice model after treated with PBS, DiR Sol, DG NPs and DG PEG_2K NPs; f The corresponding temperature changing curves of photothermal imaging in tumor site under laser treatment (808 nm, 3 W/cm², 5 min)