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. Author manuscript; available in PMC: 2021 Sep 21.
Published in final edited form as: Birth Defects Res. 2019 Aug 30;112(1):19–39. doi: 10.1002/bdr2.1581

Figure 11.

Figure 11.

Integrated cleft palate AOPs. An analysis of HTS data, chemotypes, and evidence from mining the biomedical literature resulted in a networked set of cleft palate AOPs. (RA- retinoic acid; GPCR – g-protein coupled receptors; GRs – glucocorticoid receptors; RTKs – receptor tyrosine kinases; GF – growth factor; MMP - matrix metalloproteinases; /TIMP -Tissue Inhibitor of Metalloproteinase; TGF – transforming growth factor; ECM - extracellular matrix; EMT - epithelial-mesenchymal transition; MEE - medial edge epithelial)