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. Author manuscript; available in PMC: 2021 Sep 21.
Published in final edited form as: Psychopharmacology (Berl). 2020 Jun 29;237(9):2823–2833. doi: 10.1007/s00213-020-05575-z

Figure 2: Effect of housing conditions in adolescent vs adult-onset Coc-SA and cocaine-seeking behavior during adulthood.

Figure 2:

Behavior during Non-ABRV Coc-SA, EXT and Coc-Pair TEST for (A-D) adolescent and (E-H) adult rats. Mean (±SEM) of active and inactive lever responses during (A, E) Coc-SA for adolescent and adult rats and number of infusions, (B, F) 1 hr EXT sessions, (C, G) the last 1 hr EXT session and 1 hr Coc-Pair TEST, (D, H) during 10 min Bins of the 1 hr Coc-Pair TEST. Symbols indicate significant within-subject (#, †) or between-subject (*) differences revealed by Tukey’s test, p<0.05. (B, F) # EXT S1>8, (C, G) # last session of EXT>Coc-Pair TEST, (D, H) * Time Bin 1>6, † Time Bin 2>6, * Housing differences (F) EXT S1, (C, G) Coc-Pair TEST, (H) during first 10 min of TEST. Circles indicate adolescent group; triangles indicate adult group.