Table 3.

Univariable Cox proportional hazard model analysis in the training set (S_T) for HPV+ and HPV− patients.

Variables	HPV+ patients		HPV− patients
	HR (95% CI)	p-value	HR (95% CI)	p-value
Gender (female vs. male)	1.32 (0.78–1.84)	0.41	1.12 (0.63–1.86)	0.97
Smoking history
(current smoker vs. non-/ex-smoker)	1.36 (0.54–3.39)	0.39	1.04 (0.63–1.73)	0.87
Drinking history
(moderate/heavy drinker vs. non-/ex-/light drinker)	1.66 (1.05–2.42)	0.02	1.21 (0.72–2.05)	0.47
T stage
T1	Ref		Ref
T2	1.26 (0.42–3.78)	0.82	0.88 (0.32–2.39)	0.80
T3	2.9 (1.03–8.15)	0.03	1.11 (0.42–2.91)	0.83
T4	2.9 (0.84–10.13)	0.09	1.17 (0.42–3.22)	0.76
N stage
N0	Ref		Ref
N1	0.71 (0.26–1.96)	0.51	2.12 (0.89–4.13)	0.14
N2	0.82 (0.27–2.46)	0.72	2.61 (1.25–5.41)	0.01
N3	1.47 (0.35–6.20)	0.59	2.40 (0.85–6.75)	0.10
Overall stage (AJCC eighth edition)
I	Ref		Ref
II	1.81 (0.82–3.99)	0.14	1.02 (0.55–1.90)	0.94
III	2.19 (0.85–5.68)	0.11	1.27 (0.66–2.42)	0.47
RRSHPV+
(RRSHPV−)	29.45 (7.2–120)	<0.0001	6.28 (2.06–19.16)	0.0007

Bold values refer to significant p values < 0.05.