FIGURE 2.
Landscape of m6A RNA methylation regulators in LN. (A) m6A RNA methylation modification regulated by m6A “writer,” “reader,” and “eraser,” which is involved in the immune microenvironment of LN. (B) Protein-protein interaction (PPI) network composed of 23 m6A regulators. (C) Violin plot demonstrating the expression level of 18 m6A regulators in glomeruli between living donor and LN. (D) Violin plot demonstrating the expression level of 17 m6A regulators in tubulointerstitium between living donor and LN. (E) Violin plot demonstrating the expression level of 21 m6A regulators in kidney whole tissue between living donor and of LN. (F) Volcano plot showing a summary of the expression differences of 18 m6A regulators between the healthy and LN patients’ glomerular samples. (G) Correlations between 18 m6A regulators in LN glomeruli samples. The two respective scatterplots show the two pairs of m6A regulators with the highest correlation, HNRNPA2B1 and RBM15B with the most negative correlation, and YTHDC1 and FMR1 with the most positive correlation.