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. 2021 Sep 7;9:724837. doi: 10.3389/fcell.2021.724837

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Copyright © 2021 Zhao, Pan, Duan, Liu, Li, Liu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of two distinct m⁶A modification subtypes in LN and clinical correlation of two subtypes. (A) Consensus clustering of cumulative distribution function (CDF) for k = 2–9. (B) Elbow plot shows relative change in area under CDF curve. (C) Consensus clustering matrix for k = 2. (D) Principal component analysis (PCA) of two m⁶A subtypes in LN. (E) Heatmap of the clinical features of two clusters comparing the stages of LN and gene profiles between m⁶A subtypes in GSE127797. (F) The two m⁶A subtypes exhibit distinct expression statuses of 18 m⁶A RNA methylation regulators.