Table 3.
Ad Hoc Analysis of the Presence and Concentration of Vaginal Lactobacilli, Other Cervicovaginal Microbiota, and Sexually Transmitted Infection in Participants With a Moderate to High Concentration of Schistosoma DNA (Ct < 35) Compared With FGS-Negative Participants
| Organism | No. (%) and Concentrationa | FGS Negative (n = 158) | FGS With Ct < 35 (n = 16) | P Valueb |
|---|---|---|---|---|
| L. crispatus | Presence | 49 (31.0) | 6 (37.5) | .60 |
| Median (IQR) | 1.1×107 (2.6×105–7.0×108) | 1.2×106 (3.0×105–2.0×107) | .28 | |
| Log-concentration mean | 16.38 | 14.27 | .19 | |
| L. iners | Presence | 113 (71.5) | 11 (68.75) | .82 |
| Median (IQR) | 2.8×108 (3.9×107–1.6×109) | 7.5×107 (3.6×106–7.5×108) | .30 | |
| Log-concentration mean | 18.98 | 17.86 | .21 | |
| G. vaginalis | Presence | 115 (72.8) | 13 (81.3) | .46 |
| Median (IQR) | 8.1×106 (7.7×105–4.8×107) | 1.5×107 (3.8×106–3.1×108) | .11 | |
| Log-concentration mean | 15.74 | 17.45 | .03 | |
| A. vaginae | Presence | 112 (70.9) | 13 (81.3) | .38 |
| Median (IQR) | 5.8×107 (8.7×106–2.0×108) | 1.6×108 (1.6×107–2.8×108) | .70 | |
| Log-concentration mean | 17.33 | 17.38 | .95 | |
| T. vaginalis | Presence | 34 (21.5) | 8 (50.0) | .01 |
| Median (IQR) | 1.7×105 (56.9–6.3×106) | 8085.0 (5210.0–1.0×106) | .56 | |
| Log-concentration mean | 10.88 | 10.09 | .70 | |
| Vaginal microbiota with prevalence <20% | ||||
| N. gonorrheae | Presence | 12 (7.6) | 0 (0.0) | .61 |
| C. trachomatis | Presence | 13 (8.2) | 2 (12.5) | .63 |
| M. genitalium | Presence | 7 (4.4) | 0 (0.0) | 1.0 |
| C. albicans | Presence | 8 (5.1) | 2 (12.5) | .23 |
Abbreviations: Ct, cycle threshold; FGS, female genital schistosomiasis; IQR, interquartile range.
aConcentrations are expressed in genome equivalents/mL.
bFor species with >20% prevalence, P values for presence, median (IQR), and log-concentration mean are from the chi-square test, rank-sum test, and t test, respectively. For species with <20% prevalence, P values for presence are from the Fisher exact test.