Figure 1.

Summary of the Role of AMH in AMH Null Mice

In AMH-null female mice 25 days after birth (equivalent to female puberty in humans), the number of primordial follicles was normal, but the numbers of activated follicle were elevated.¹² In 4 months old, AMH-null female mice (equivalent to reproductive middle age in humans), the number of primordial follicles was significantly reduced, while the number of activated follicles was significantly higher than normal, together with larger ovarian volume.¹² At 13 months old in AMH-null female mice (equivalent to the perimenopausal period in humans), the primordial and activated follicle numbers decreased significantly in AMH-null compared with control mice. The scheme is based on the data from Durlinger et al.¹² (https://doi.org/10.1210/endo.140.12.7204).