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Mechanism of RNA m6A Modifications
The m6A modification is catalyzed by the “writer” proteins including METTL3, METTL14, WTAP, METTL5, METTL16, ZCCHC4, VIRMA, RBM15/15B, HAKAI, and ZC3H13. The m6A methylation is removed by “eraser” proteins FTO or ALKBH5. “Reader” proteins recognize m6A modifications and determine targeted RNA destiny.
