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. 2021 Sep 14;478(17):3297–3317. doi: 10.1042/BCJ20210175

Figure 1. Alteration of expression of Grb2 and NOX4 in clinical, in AD or T2D mimicking mouse.

Figure 1.

(A) Western blot showing the NOX4 and GAPDH levels in AD whole brain lysate. (B) Histogram representing the mean value of optical density of the bands, normalized against GAPDH. NOX4 was overexpressed by 1.86 fold in AD Brains. (C) Shows NOX4 transcript level being up-regulated by 5.06 fold by qRT-PCR of APP/PS1 mouse brain tissue. (D) Western blot showing Grb2, NOX4 and GAPDH levels in T2D whole liver lysate. (E and F) Histograms representing the mean values of Grb2 and NOX4 normalized against GAPDH. Grb2 and NOX4 were overexpressed in T2D liver by 5.27 fold and 2.4 fold, respectively. (G and H) show qRT-PCR results inT2D mouse model where C57BL/6 mice are maintained in OWD, Grb2 and NOX4 transcript levels are overexpressed by 3.01 fold and 1.45 fold, respectively. (I and J) the transcript levels of miR-1271 in AD and T2D cell model, respectively. All the statistical information is compiled in Supplementary Table S7.