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. 2021 Sep 14;478(17):3297–3317. doi: 10.1042/BCJ20210175

Figure 2. Role of PAX4 in transcription of Grb2 and NOX4.

Figure 2.

(A) shows the transcript level alterations of −3.6 fold for Nkx2-5, +4.19 fold for PAX4 and +2.89 fold for FOXD3 in AD (AICD + Aβ) cell models compared with control. Similarly, (B) shows the transcript level alterations of −2.59 fold for Nkx2-5, +4.88 fold for PAX4 and +4.39 fold for FOXD3 in T2D (+PA, +Amylin, +Insulin) cell models compared with controls. (C) shows PAX4 protein overexpression by 1.8 and 2.00 folds by Western Blot in (D) AD patients’ whole brain samples and (E) T2D patients’ whole liver samples, respectively. The alterations in transcript levels of (F) endogenous PAX4 [in SHSY5Y 2.99 fold and in HepG2 1.58 fold], (G) GRB2 [in SHSY-5Y 1.16 fold and in HepG2 1.52 fold], and (H) NOX4 [in SHSY5Y 2.83 fold and in HepG2 2.3 fold] in PAX4 knockdown situation in SHSY5Y and HepG2 cell lines. All statistical information is compiled in Supplementary Table S7.