TABLE 2.
Biopsy findings of the patient cohort
AMR | Mixed | ACR | ATN | |
---|---|---|---|---|
Histopathology classification (no. of cases) | 32 | 20 | 16 | 12 |
Acute active rejection | 29 | 19 | 16 | 0 |
Chronic active rejection | 3 | 1 | 0 | 0 |
Chronic inactive rejection | 0 | 0 | 0 | 0 |
Histopathology features, median (IQR) | ||||
i | 0 (0–0.75) | 2 (1.7–3) | 2 (1.7–2) | 0 (0–0) |
t | 0 (0–0) | 2 (2–3) | 3 (2.7–3) | 0 (0–0) |
ti | 0 (0–1) | 2 (2–3) | 2 (2–3) | 0 (0–0) |
g | 1 (0–2) | 0 (0–2) | 0 (0–0) | 0 (0–0) |
ptc | 0.5 (0–1.75) | 2 (1–2) | 1 (0–1) | 0 (0–0) |
cg | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) |
mm | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) |
v | 0 (0–0) | 1 (0–1) | 0 (0–0) | 0 (0–0) |
ci | 0 (0–0) | 1 (0–1) | 1(0–1) | 0 (0–0) |
ct | 0 (0–0) | 1 (0–1) | 1 (0.7–1) | 0 (0–1) |
ah | 0 (0–1) | 1 (0–1) | 0 (0–1) | 0 (0–0) |
cv | 0 (0–2) | 1 (0–1.5) | 1 (0–1.7) | 1 (0–1) |
C4d | 3 (3–3) | 3 (2–3) | 0 (0–0) | 0 (0–0) |
Globally sclerosed glomeruli (%) | 3.8 (0–7.5) | 5 (0–11.3) | 4 (0–10.8) | 4 (0–6.3) |
Histopathology lesions were evaluated according to the most updated Banff classification.
ACR, acute cellular rejection; ah, arteriolar hyalinosis; AMR, antibody-mediated rejection; ATN, acute tubular necrosis; c4d, c4 deposition; cg, chronic glomerulopathy; ci, interstitial fibrosis; ct, tubular atrophy; cv, vascular fibrous intimal thickening; g, glomerulitis; i, interstitial inflammation; IQR, interquartile range; mm, mesangial matrix expansion; ptc, peritubular capillaritis; t, tubulitis; ti, total inflammation; v, intimal arteritis.