TABLE 2.
Characteristics of 11 deaths in the cohort during extended follow-up
| Patient | Baseline Immunosuppression | Immunosuppression switch | Cause of switch (d post-LTx to switch) | Cause of death | Time to death post-LTx, d | Primary graft (if not, cause of retransplantation) | Related to surgery or immunosuppression |
|---|---|---|---|---|---|---|---|
| 1 | CyA-ME | No | – | Intractable seizures | 473 | Yes | Seizures related to CyA-ME use |
| 2 | CyA-ME | Yes (Tac) | 3rd episode of acute rejection (233) | CLF and HOCM | 576 | No (PVT) | CLF related to PVT after surgery. HOCM related to Tac use |
| 3 | CyA-ME | No | – | PTLD | 1041 | Yes | Related to immunosuppression |
| 4 | Tac | No | – | GI bleed | 637 | Yes | Surgical—Budd-Chiari |
| 5 | Tac | No | – | PTLD | 658 | Yes | Related to immunosuppression |
| 6 | Tac | Yes (CyA-ME) | Renal dysfunction (162) | Unknown | 853 | Yes | Unknown |
| 7 | CyA-ME | Yes (Tac) | Chronic rejection (520) | Multiple organ failure | 4188 | No (cryptogenic cirrhosis) | Unknown |
| 8 | CyA-ME | No | – | GI bleed | 2221 | Yes | Unknown |
| 9 | Tac | No | – | Respiratory failure and sepsis | 2523 | Yes | CF related |
| 10 | CyA-ME | Yes (Tac) | Steroid-resistant rejection (25) | Intraoperative death | 2749 | No (chronic rejection) | Complications during surgery |
| 11 | Tac | No | – | Hemolytic anemia causing multiorgan failure | 3085 | Yes | Pulmonary hypertension + noncompliant |
CF, cystic fibrosis; CLF, chronic liver failure; CyA-ME, cyclosporine A microemulsion; GI, gastrointestinal; HOCM, hypertrophic cardiomyopathy; LTx, liver transplantation; PTLD, posttransplant lymphoproliferative disease; PVT, portal vein thrombosis; Tac, tacrolimus.