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. 2021 Sep 20;8(5):ENEURO.0143-21.2021. doi: 10.1523/ENEURO.0143-21.2021

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Copyright © 2021 Borrelli et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 11. — Functional network plot of differential brainstem gene expression on P15 following repeated neonatal morphine exposure. Plots represent gene expression relative to saline controls in sex-collapsed dataset [n = 6 saline (3 females, 3 males), n = 6 morphine (3 females, 3 males). Central color coding of individual genes reflects LogFC from −2.80 (blue) to 2.80 (red). Donut plots are color coded to reflect enriched GO Biological Process networks. All genes with unadjusted p values < 0.10 were included in functional network identification. Plots were generated using Cytoscape software, and gene interactions were imported from the STRING database to reflect known gene interactions (shown via interconnecting lines, increased line opacity represents stronger known gene interaction). Complete enrichment data for the sex-collapsed analysis are presented in Extended Data Figure 11-1.