Table 3.
Differentially expressed gene transcripts (p < 0.05) that significantly correlated (p < 0.05) with NOWS-model phenotypes on P14
| Phenotypes | Overlapping phenotypes, n |
Genes, n |
Differentially expressed genes (MOR) correlated with phenotypic data |
|---|---|---|---|
| Hot plate latency; normalized body weight; USVs per minute; USV distance |
4 | 1 | Prokr1 |
| Hot plate latency; normalized body weight; USVs per minute |
3 | 3 | Smtnl2, Alox5ap, Adamts16 |
| Normalized body weight; USVs per minute |
2 | 15 |
Hist1 h2bc, Id2, Spata32, Krt25, Hist3 h2a, Cox7b2, Zmym3, Naa40, Col6a6, Srrm4, Emcn, Hpse, Miat, Mapk1ip1, Lncppara |
| Normalized body weight; hot plate latency |
2 | 8 | Nlrc5, Wnt8b, Tbx3os1, Pla2g4b, Fcmr, Prickle3, Cdca5, Prdm6 |
| Normalized body weight; tail withdrawal latency |
2 | 4 | Myo1a, Plpp5, Mir3060, Mis18a |
| Tail withdrawal latency; USVs per minute |
2 | 1 | Magel2 |
| Tail Withdrawal Latency | 1 | 19 |
Selenov, Myom3, Ebna1bp2, Il27ra, Fam92b, Ccdc116, Vipr1, Ccr2, Prkcg, Rsg1, Pisd-ps1, Pisd, Arg2, Mfsd11, Mfap5, Msr1, Ifi207, Foxc2, Fggy |
| Normalized body weight | 1 | 14 |
Tcea2, Mtln, Thsd7b, Snapc1, Klf2, Mirg, Galnt15, Ccdc150, Cdk2, Mms22l, Melk, Ccdc15, Tdgf1, Hoxc6 |
| USVs per minute | 1 | 11 |
Timp1, Chrdl2, Cldn11, Rfc5, Plekhg4, Myh8, Snrnp200, Cpsf4l, Gng11, Wdr66, Fat2 |