Figure 3.

PGs produced during SR‐A‐mediated adhesion modulate TNF‐α and IL‐10 production. MPMs from SR‐A^+/+ or SR‐A^−/− mice were isolated and pretreated in the absence (Control) or presence of indomethacin (10 μM) for 30 min before plating on gluc‐collagen‐coated plates. After 24 h, the culture medium was removed and assayed for TNF‐α (A) or IL‐10 (B) by ELISA. The graph depicts the mean ± sem of at least 3 separate experiments. Log‐transformed data were analyzed by 1‐way ANOVA. Significant differences (*P < 0.05) from untreated SR‐A^+/+ control macrophages by use of a Dunnett's post hoc test.