Figure 4.
Multiple COX‐derived AA products are produced during SR‐A‐mediated macrophage adhesion. MPMs from SR‐A+/+ or SR‐A−/− mice were isolated and pretreated in the absence (Control) or presence of indomethacin (10 μM) for 30 min before plating on gluc‐collagen‐coated plates. After 1 h, the culture medium was removed and assayed by ELISA for PGE2 (A), the stable PGI2 metabolite 6‐keto‐PGF1 α (B), and the stable TXA2 metabolite TXB2 (C). The graph depicts the mean ± sem of at least 3 separate experiments. Log‐transformed data were analyzed by 1‐way ANOVA. Significant differences (*P < 0.05) from untreated SR‐A+/+ control macrophages by use of a Dunnett's post hoc test.