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. 2015 Feb 25;97(5):901–908. doi: 10.1189/jlb.2A1014-471RR

Figure 5.

Figure 5

Exogenous PG agonists differentially regulate cytokine production during SR‐A‐mediated macrophage adhesion. MPMs from SR‐A+/+ mice were isolated and pretreated in the absence (Control) or presence of indomethacin (10 μM) for 30 min. As indicated, exogenous PGE2 (0.1 μM), the stable PGI2 analog cicaprost (0.1 μM), or the stable TXA2 analog U46619 (0.1 μM) was added and cells plated on gluc‐collagen‐coated plates. After 24 h, the culture medium was removed and assayed for TNF‐α (A) or IL‐10 (B). The graph depicts the mean ± sem of at least 3 separate experiments. Data were analyzed by 1‐way ANOVA. Significant differences (*P < 0.05) from untreated SR‐A+/+ control macrophages by use of a Dunnett's post hoc test.