Figure 6.

PG antagonists differentially regulate cytokine production during SR‐A‐mediated macrophage adhesion. MPMs from SR‐A^+/+ mice were isolated and left untreated (Control) or pretreated in the presence of indomethacin (10 μM) for 30 min or for 5 min with GW627368X (10 μM), AH6809 (10 μM), or CAY10441 (10 μM). Cells were then plated on gluc‐collagen‐coated plates, and after 24 h, the culture medium was removed and assayed for TNF‐α (A) or IL‐10 (B). The graph depicts the mean ± sem of at least 3 separate experiments. Data were analyzed by 1‐way ANOVA. Significant differences (*P < 0.05) from untreated control macrophages, determined by use of a Dunnett's post hoc test.