Table 1. Effect of B2AR-C184Y mutation on isoproterenol dependent CRE-mCherry activity.
Cell Background | Plasmid | N | p[A]50 | Emax | α |
---|---|---|---|---|---|
HEK-CRE-mCherry | Non-transfected | 3 | 8.29±0.3 | 19.65±5.5 | 0.25 |
B2AR-wt | 3 | 9.03±0.6 | 79.06±22.8 | 1.0 | |
B2AR-C184Y | 3 | 7.59±0.4 | 68.70±29.7 | 0.87 | |
HEK-CRE-mCherry B2AR-KO | Non-transfected | 3 | N/A | 3.23±0.3 | 0.05 |
B2AR-wt | 3 | 9.28±0.4 | 64.64±16.7 | 1.0 | |
B2AR-C184Y | 3 | 7.55±0.4 | 55.00±28.5 | 0.85 |