Fig 2. Corrected QT interval and RR interval relationships by correction method and individual study.

QT intervals adjusted with study-specific ($QTcS=\frac{QT}{{RR}^{{\beta }_{age}}}$, where β_age decreased with increasing age), Fridericia ($QTcF=\frac{QT}{\sqrt[3]{RR}}$), and Bazett heart rate corrections ($QTcB=\frac{QT}{\sqrt{RR}}$) and their relationship with RR intervals in the pooled dataset (top panels) and by individual study (bottom panels) with means (blue line) and 95% CIs (shaded area) from linear regression. A slight positive relationship is expected even with ideal correction because of confounding by body temperature changes, i.e., fever and defervescence, in malaria.