Fig. 8. Redox-sensitive metabolites are altered in HsFN3K knockout cells.

(A)¹H NMR spectra of WT and FN3K-knockout (FN3K-KO) HepG2 cells. Traces are the average for each group (WT N=10, FN3K-KO N=9). Insets highlight examples of regions containing annotated metabolites observed to be significantly different between cell lines. (B) Box and whisker plots of significant (FDR p-value < 0.05) metabolites annotated with highest confidence. Black points indicate outliers. Two-tailed T-test was performed, and the p-values were corrected for false discovery rate using the Benjamini-Hochberg method.