Table 2.
Comparison of the demographic data among participants with normal cognition, subjective cognitive decline, mild cognitive impairment, and mild dementia in the test phase.
| NC, mean (SD) | SCD, mean (SD) | MCI, mean (SD) | MD, mean (SD) | f/χ2 | p-value | |
|---|---|---|---|---|---|---|
| N | 642 | 741 | 986 | 2,012 | ||
| Age, years | 63.2 (13.6) | 66.3 (12.0) | 70.4 (11.0) | 77.2 (10.1) | 345.3 | <0.001a |
| CDR, 0/0.5/1 | 642/0/0 | 248/493/0 | 0/986/0 | 0/1045/967 | 4516.2 | <0.001a |
| CDR-SB | 0.0 (0.1) | 0.4 (0.3) | 1.3 (0.6) | 4.4 (2.4) | 1990.5 | <0.001b |
| Female, N (%) | 292 (45.5) | 381 (51.4) | 478 (47.5) | 1170 (58.2) | 44.8 | <0.001c |
| Education | 9.9 (6.9) | 8.9 (4.6) | 7.5 (5.4) | 4.7 (4.8) | 242.3 | <0.001d |
| IADL | 7.8 (0.9) | 7.8 (0.6) | 7.0 (1.5) | 3.2 (2.6) | 1830.9 | <0.001e |
| MoCA | 23.0 (5.9) | 22.3 (5.3) | 18.3 (5.3) | 9.0 (5.4) | 1864.0 | <0.001e |
| CASI | 85.7 (13.2) | 85.4 (9.3) | 78.2 (9.6) | 52.0 (18.3) | 1622.5 | <0.001e |
| NPI | 2.1 (4.0) | 2.9 (4.6) | 4.9 (7.2) | 6.7 (8.9) | 90.2 | <0.001b |
| Diagnostic group AD/VCI/LBD/OD |
436*/77/107/22 | 544*/73/104/20 | 650*/102/177/57 | 1036/412/390/174 | 179.6 | <0.001f |
NC, normal cognition; SCD, subjective cognitive decline; MCI, mild cognitive impairment; MD, mild dementia; AD, Alzheimer's disease; VCI, vascular cognitive impairment; LBD, Lewy body disease; OD, other disorders; CDR, Clinical Dementia Rating Scale; CDR-SB, Sum of boxes of the Clinical Dementia Rating Scale; IADL, Instrumental Activities of Daily Living; MoCA, Montreal Cognitive Assessment; CASI, Cognitive Abilities Screening Instrument; NPI, Neuropsychiatric Inventory.
Participants with NC/SCD/MCI without CVD, parkinsonism, or other brain disorders were divided and analyzed in the AD group. Post-hoc analysis: a: NC < SCD < MCI < MD; b: NC = SCD < MCI < MD; c: NC < SCD < MD, NC = MCI, SCD = MCI, MCI < MD; d: NC > SCD > MCI > MD; e: NC = SCD > MCI > MD; f: NC = SCD ≠ MCI ≠ MD.