Table 3.
Comparison of sensitivity, specificity, area under the curve (AUC), and cutoff score among participants with Alzheimer's disease*, vascular cognitive impairment, Lewy body disease, other disorders, and all participants with a sum of boxes of the clinical dementia rating scale in the test phase.
| AD* | VCI | LBD | OD | All | |
|---|---|---|---|---|---|
| N | 2,666 | 664 | 778 | 273 | 4,381 |
| SCD vs. NC | |||||
| N, SCD/NC | 544/436 | 73/77 | 104/107 | 20/22 | 642/741 |
| Sensitivity | 0.68 | 0.63 | 0.87 | 0.80 | 0.71 |
| Specificity | 0.98 | 0.94 | 0.97 | 0.95 | 0.98 |
| AUC | 0.83 | 0.79 | 0.91 | 0.88 | 0.84 |
| AUC 95%CI | 0.81–0.86 | 0.72–0.87 | 0.87–0.96 | 0.77–0.99 | 0.82–0.86 |
| Cutoff | 0/0.5 | 0/0.5 | 0/0.5 | 0/0.5 | 0/0.5 |
| MCI vs. SCD | |||||
| N, MCI/SCD | 650/544 | 102/73 | 177/104 | 57/20 | 986/741 |
| Sensitivity | 0.73 | 0.91 | 0.99 | 0.97 | 0.81 |
| Specificity | 0.90 | 0.96 | 0.97 | 0.85 | 0.92 |
| AUC | 0.86 | 0.96 | 0.99 | 0.97 | 0.90 |
| AUC 95%CI | 0.84–0.89 | 0.94–0.99 | 0.97–1.00 | 0.93–0.99 | 0.89–0.92 |
| Cutoff | 0.5/1.0 | 0.5/1.0 | 0.5/1.0 | 0.5/1.0 | 0.5/1.0 |
| MD vs. MCI | |||||
| N, MD/MCI | 1036/650 | 412/102 | 390/177 | 174/57 | 2012/986 |
| Sensitivity | 0.74 | 0.80 | 0.82 | 0.81 | 0.80 |
| Specificity | 0.97 | 0.92 | 0.97 | 0.84 | 0.91 |
| AUC | 0.92 | 0.93 | 0.93 | 0.87 | 0.92 |
| AUC 95%CI | 0.91–0.93 | 0.90–0.95 | 0.91–0.95 | 0.82–0.91 | 0.91–0.93 |
| Cutoff | 2.0/2.5 | 2.5/3.0 | 2.5/3.0 | 2.5/3.0 | 2.0/2.5 |
AD*, Alzheimer's disease and participants with NC/SCD/MCI without CVD, parkinsonism, or other brain disorders; VCI, vascular cognitive impairment; LBD, Lewy body disease; OD, other disorders; SCD, subjective cognitive decline; NC, normal cognition; MCI, mild cognitive impairment; MD, mild dementia.