FIG 1.

Study design and sample coverage across ceca and lung samples. (A) Study timeline for the mouse study. Six-week-old female mice were inoculated with PBS and low or high titers of SARS-CoV-2 virus. Three groups of mice were administered antiviral GC-376 twice per day starting 3 h after inoculation until 7 dpc (indicated by top arrows). Lung and cecum samples were collected at 2, 5, and 14 dpc (indicated by the stars). Lung samples were collected in vehicle and GC-376 groups, while cecum samples were collected from the vehicle group. (B) Sequencing coverage of the extraction blank, PCR blank, and samples (cecum, yellow; lung, red). Coverage mean is indicated above the boxplot. Outliers are indicated by points outside the plot. Three outliers for the ceca (>80,000) are not shown.