Fig. 2.

Structure of the two polyamides that target the ERRE site. Polyamide 1 and 2 are consisted of two polyamide strands covalently linked by a γ-aminobutyric acid (γ-turn) linker. Within this structure design, the Py/Im pair target C/G; Im/Py pair target G/C; Py/Py target A/T or T/A. The γ-turn linker has demonstrated selectivity for A, T over G, C. For each panel: top, chemical structure of the polyamides; bottom, the ball-and-stick models with the target sequence of polyamides shown together. Solid circle, imidazole; Open circle, pyrrole. IPA isophthalic acid