Table 1:

Mathematical model parameters and their ranges.

Parameter	Description	Value	Reference

	Time in days
$\begin{matrix} t \\ s (t) := \frac{S (t)}{K} \\ r (t) := \frac{R (t)}{K} \end{matrix}$	Sensitive cell density (normalized)	0.0 – 1.0
	Resistant cell density (normalized)	0.0 – 1.0
$n (t) := \frac{S (t) + R (t)}{K}$	Total tumor cell density (normalized)	0.0 – 1.0
d(t) = D(t)/D_Max	Drug dose (normalized)	0.0 – 1.0
r_s	Sensitive cell proliferation rate and model time scale	0.027d⁻¹	Adopted from [10].
${\hat{r}}_{R} := \frac{r_{R}}{r_{S}}$	Resistant cell proliferation rate (normalized)	0.5 – 1.0	Lower limit: [12]; Upper limit: assumption of no cost
K	Environmental carrying capacity and scale for cell densities	n/a	Defined implicitly via n₀
${\hat{d}}_{T} := \frac{d_{T}}{r_{S}}$	Cell turnover rate (normalized)	0.0 – 0.5	Lower limit: assumption of no turnover; Upper limit: see Section S6
d^_D := 2d_D	Drug-induced cell kill (see text for further explanation)	1.5	Adopted from [28]
D _Max	Maximum tolerated dose	n/a	Implicitly defined via d^_D.
$n_{0} := \frac{N_{0}}{K}$	Initial tumor cell density (normalized)	0.1 – 0.75	Parameter sweep; values within this range reported by [33]
$f_{R} := \frac{R_{0}}{N_{0}}$	Initial resistant cell fraction	0.001 – 0.1	Parameter sweep; values within this range reported by [24]