Figure 4.

Exploration of treat/holiday space for intermittent BRAFi combined with continuous FAKi to maximize control of tumor burden. Surface plot of Π (see equation (3)) in the treat/holiday space.

Model parameterized on mouse IX of cell line 5555. ρ_S = 0.66325 1/day, ρ_R = 0.49543 1/day, K = 4818.62 mm³, $\tilde{\eta }$ = 26.876 1/day, $\tilde{\alpha }$ = 14.4 1/day, θ = 0.03 1/day, ξ = 0.01 1/day, φ = 1 1/day, S₀ = 48 mm³, R₀ = 12 mm³, F₀ = 60 mm³, A₀ = 0 mm³. The star indicates the treatment schedule simulated in Figure 5.