Figure 5.

Example of combination therapy schedule (BRAFi+FAKi) to exploit tumor-stroma interactions. The model is parameterized as reported in Figure 4. Bands above the graph indicate the BRAFi and FAKi administration windows. The BRAFi is intermittently administered for 1 days with 2 days holiday. The FAKi is continuously administered. This treatment schedule delays the disease progression by approximately ten days (compare solid and dashed S(t) + R(t) curves) while using a third of the BRAFi dose.