Table 1.

Summary of Randomized Trials Comparing Diosmin and Micronized Purified Flavonoid Fraction for the Treatment of Chronic Venous Disease

Study	Design	Study Groups	Study Objective	Duration	Inclusion Criteria	Primary Evaluation Criteria	Efficacy Results
Henriet (1995)17	Multicentric randomized double-blind study	Diosmin 600 (n=34) MPFF 500 (n=35)	To compare: Diosmin 600 mg once a day and MPFF 500 mg twice a day	28 days	Women 18 to 45 y suffering ≥6 months from functional symptoms of CVD (pain and/or heaviness in the lower limbs)	Weekly patient self-assessment (VAS) of pain/heaviness at D0, D7, D14, D21 and D28	Change from baseline of pain/heaviness assessed by patients significantly improved: p < 0.0001 at each time point from D7 to D28 No difference between groups
Maruszynski (2004)18	Multicentric randomized double-blind study	Diosmin 600 (n=59) MPFF 500 (n=60)	To compare: Diosmin 600 mg once a day and MPFF 500 mg twice a day	28 days	Women 20 to 60 y with CVD symptoms (C0-C3)	Weekly patient self-assessment (sum of individual scores of functional symptoms) at D0, D7, D14, D21 and D28	Significant decrease in symptoms in both groups No difference between treatment groups
Steinbruch (2020)19	Multicentric non-inferiority single-blind randomized study	Diosmin 600 (n=57) MPFF 1000 (n=57)	To assess the non-inferiority of diosmin 600 mg once a day compared to MPFF 1000 mg once a day	6 months	Patients with CVD symptoms (C0-C3) between 20 and 60 mm of a 100-mm VAS (patient self-assessment)	Self-assessment (VAS) at M0, M2, M4 and M6 of venous symptoms in CVD patients	Non-inferiority was demonstrated Significant improvement of symptoms from M2, maximal at M6, in both groups (p < 0.0001)

Abbreviations: CVD, chronic venous disease; D, day; M, month; MPFF, micronized purified flavonoid fraction; VAS, visual analog scale; y, years.