. 2021 Sep 16;17:591–600. doi: 10.2147/VHRM.S324112

Table 2.

Summary of Adverse Reactions Reported During the Randomized Trials

Study	Non-Micronized Diosmin 600 mg	MPFF 1000 mg
Henriet (1995)¹⁷	Vomiting and diarrhoea (n=1), gastralgia (n=1), headache (n=1) (n=3/34)	Gastralgia (n=3), constipation and abdominal meteorism (n=1), nausea (n=1) (n=5/35)
Maruszynski (2004)¹⁸	Calf, hand and feet oedema, body rash (n=NI/59)	Calf oedema, body rash, mouth dryness (n=NI/60)
Steinbruch (2020)¹⁹	Nausea (13.3%), dyspepsia (16.7%), diarrhoea (8.3%), headache (6.7%), vertigo (6.7%) (n=21/57)	Nausea (20%), dyspepsia (6.7%), diarrhoea (5.0%), headache (6.7%), vertigo (3.3%) (n=16/57)

Abbreviations n, Number of patients experiencing adverse reaction; NI, Not indicated; MPFF, micronized purified flavonoid fraction.