Table 1.
Characteristics of each study.
Study | Registered number | Design | Participants | Intervention | Dosage | Follow-up | Outcomes | |
---|---|---|---|---|---|---|---|---|
MSC group | Control group | |||||||
Amirdelfan et al. [18] 2021 | NCT01290367 | RCT | 80 | MSC+HA | HA | 6 × 106, 1.8 × 107 | 36 m | VAS,ODI, AE, CSC, MIC |
Noriega et al. [17] 2021 | NCT01860417 | RCT | 24 | MSC | Mepivacaine | 2.50 × 107 | 42 m | VAS, ODI, AE |
Noriega et al. [15] 2017 | NCT01860417 | RCT | 24 | MSC | Mepivacaine | 2.50 × 107 | 12 m | VAS, ODI, AE |
Note: AE: adverse event; CSC: clinically significant change; HA: hyaluronic acid; ODI: Oswestry Disability Index; MIC: minimally important change; MSC: mesenchymal stem cell; RCT: randomized controlled trial; VAS: visual analog scale.