Table 2.
Target-gene pairs of active ingredients of PRA.
| Target gene | Gene name |
|---|---|
| 26S proteasome non-ATPase regulatory subunit 3 | PSMD3 |
| 5-Hydroxytryptamine 2A receptor | HTR2A HTR2 |
| 5-Hydroxytryptamine receptor 3A | HTR3A |
| Acetylcholinesterase | ACHE |
| Activator of 90 kDa heat shock protein ATPase homolog 1 | AHSA1 |
| Aldo-keto reductase family 1 member C3 | AKR1C3 |
| Alpha-1D adrenergic receptor | ADRA1B |
| Androgen receptor | AR |
| Antileukoproteinase | SLPI |
| Apoptosis regulator BAX | BAX |
| Apoptosis regulator Bcl-2 | BCL2 |
| Arachidonate 5-lipoxygenase | ALOX5 |
| Aryl hydrocarbon receptor | AHR |
| Beta-2 adrenergic receptor | ADRB2 ADRB2R, B2AR |
| Beta-lactamase | blaC |
| Calmodulin | CAMKK2 |
| Caspase-3 | CASP3 |
| Caspase-8 | CASP8 |
| Caspase-9 | CASP9 MCH6 |
| Catalase | CAT |
| Cell division control protein 2 homolog | CDC42 |
| CGMP-inhibited 3′,5′-cyclic phosphodiesterase A | PDE3A |
| Coagulation factor VII | F7 |
| Coagulation factor Xa | F10 |
| Cytochrome P450 1A1 | CYP1A1 |
| Cytochrome P450 1A2 | CYP1A2 |
| Cytochrome P450 1B1 | CYP1B1 |
| Cytochrome P450 3A4 | CYP3A4 |
| Cytochrome P450-cam | camC |
| Dipeptidyl peptidase IV | DPP4 |
| DNA topoisomerase II | TOP2 |
| Dopamine D1 receptor | DRD5 DRD1B, DRD1L2 |
| E-Selectin | SELE |
| Estrogen receptor | ESR1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | GABRA1 |
| Gamma-aminobutyric-acid receptor alpha-2 subunit | GABRA2 |
| Gamma-aminobutyric-acid receptor alpha-3 subunit | GABRA3 |
| Gamma-aminobutyric-acid receptor alpha-5 subunit | GABRA5 |
| Glutathione S-transferase Mu 1 | GSTM1 |
| Glutathione S-transferase Mu 2 | GSTM2 |
| Glutathione S-transferase P | GSTP1 |
| Heat shock protein HSP 90 | HSP90AA1 HSP90A, HSPC1, HSPCA |
| Heme oxygenase 1 | HMOX1 HO, HO1 |
| Hyaluronan synthase 2 | HAS2 |
| Inhibitor of nuclear factor kappa-B kinase subunit beta | IKBKB |
| Insulin receptor | INSR |
| Intercellular adhesion molecule 1 | ICAM1 |
| Interleukin-6 | IL6 |
| Interstitial collagenase | MMP1 |
| Lipopolysaccharide-binding protein | LBP |
| Microtubule-associated protein 2 | Map2 |
| Mineralocorticoid receptor | NR3C2 |
| Mitogen-activated protein kinase 8 | MAPK8 |
| Monocyte differentiation antigen CD14 | CD14 |
| mRNA of PKA catalytic subunit C-alpha | PRKACA |
| Muscarinic acetylcholine receptor M1 | CHRM1 |
| Muscarinic acetylcholine receptor M2 | CHRM2 |
| Muscarinic acetylcholine receptor M3 | CHRM3 |
| Muscarinic acetylcholine receptor M4 | CHRM4 |
| Mu-type opioid receptor | OPRM1 MOR1 |
| NAD(P)H dehydrogenase [quinone] 1 | NQO1 DIA4, NMOR1 |
| Neuronal acetylcholine receptor protein, alpha-7 chain | CHRNA7 NACHRA7 |
| Neuronal acetylcholine receptor subunit alpha-2 | CHRNA2 |
| Nitric-oxide synthase, inducible | NOS2 |
| Nitric-oxide synthase, endothelial | NOS3 |
| Nuclear receptor coactivator 2 | NCOA2 |
| Nuclear receptor subfamily 1 group I member 2 | NR1I2 |
| Pancreatic alpha-amylase | AMY2A |
| Peroxidase C1A | PRXC1A |
| Peroxisome proliferator activated receptor gamma | PPARG |
| Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform | PIK3CG |
| Potassium voltage-gated channel subfamily H member 2 | KCNH2 ERG, ERG1, HERG |
| Progesterone receptor | PGR |
| Prostaglandin G/H synthase 1 | PTGS1 |
| Prostaglandin G/H synthase 2 | PTGS2 |
| Protein kinase C-alpha type | PRKCA |
| RAC-alpha serine/threonine-protein kinase | AKT1 |
| Retinoic acid receptor RXR-alpha | RXRA |
| Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | PPP3CA |
| Serum paraoxonase/arylesterase 1 | PON1 |
| Signal transducer and activator of transcription 1-alpha/beta | STAT1 |
| Sodium channel protein type 5 subunit alpha | SCN5A |
| Sodium-dependent noradrenaline transporter | SLC6A2 |
| Solute carrier family 2, facilitated glucose transporter member 4 | SLC2A4 |
| Thrombin | F2 |
| Transcription factor AP-1 | JUN |
| Transcription factor p65 | RELA |
| Transforming growth factor beta-1 | TGFB1 |
| Trypsin-1 | PRSS1 |
| Tumor necrosis factor | TNF |