Table 3.
ROC analysis of the analyzed redox biomarkers.
| Biomarker | Saliva | Serum/plasma | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC | 95% CI | p value | Cut-off | Sensitivity % | 95% CI | Specificity % | 95% CI | AUC | 95% CI | p value | Cut-off | Sensitivity % | 95% CI | Specificity % | 95% CI | |
| CAT | 0.76 | 0.5360 to 0.9840 | 0.0494 | >0.5592 | 60 | 31.27% to 83.18% | 60 | 31.27% to 83.18% | 1 | 1.000 to 1.000 | 0.0002 | <1.244 | 100 | 72.25% to 100.0% | 100 | 72.25% to 100.0% |
| Px/GPx | 0.84 | 0.6581 to 1.000 | 0.0102 | <29.80 | 70 | 39.68% to 89.22% | 70 | 39.68% to 89.22% | 0.63 | 0.3657 to 0.8943 | 0.3258 | <35.10 | 50 | 23.66% to 76.34% | 50 | 23.66% to 76.34% |
| GR | 0.57 | 0.3009 to 0.8391 | 0.5967 | <1.719 | 50 | 23.66% to 76.34% | 50 | 23.66% to 76.34% | 0.6 | 0.3419 to 0.8581 | 0.4497 | <10.62 | 60 | 31.27% to 83.18% | 60 | 31.27% to 83.18% |
| SOD | 0.97 | 0.9071 to 1.000 | 0.0004 | <0.2066 | 90 | 59.58% to 99.49% | 90 | 59.58% to 99.49% | 1 | 1.000 to 1.000 | 0.0002 | <0.5534 | 100 | 72.25% to 100.0% | 100 | 72.25% to 100.0% |
| AA | 0.99 | 0.9583 to 1.000 | 0.0002 | <9.841 | 90 | 59.58% to 99.49% | 90 | 59.58% to 99.49% | 0.89 | 0.7500 to 1.000 | 0.0032 | <8.703 | 80 | 49.02% to 96.45% | 80 | 49.02% to 96.45% |
| GSH | 1 | 1.000 to 1.000 | 0.0002 | <0.9395 | 100 | 72.25% to 100.0% | 100 | 72.25% to 100.0% | 1 | 1.000 to 1.000 | 0.0002 | <0.4547 | 100 | 72.25% to 100.0% | 100 | 72.25% to 100.0% |
| UA | 0.9 | 0.7609 to 1.000 | 0.0025 | >0.4447 | 80 | 49.02% to 96.45% | 80 | 49.02% to 96.45% | 0.86 | 0.6739 to 1.000 | 0.0065 | >0.3867 | 80 | 49.02% to 96.45% | 80 | 49.02% to 96.45% |
| PC | 0.89 | 0.7476 to 1.000 | 0.0032 | >0.3696 | 80 | 49.02% to 96.45% | 80 | 49.02% to 96.45% | 0.95 | 0.8477 to 1.000 | 0.0007 | >0.4784 | 90 | 59.58% to 99.49% | 90 | 59.58% to 99.49% |
| 3-NT | 0.78 | 0.5536 to 1.000 | 0.0343 | >6.415 | 70 | 39.68% to 89.22% | 70 | 39.68% to 89.22% | 0.91 | 0.7557 to 1.000 | 0.0019 | >11.01 | 90 | 59.58% to 99.49% | 90 | 59.58% to 99.49% |
| AGE | 0.94 | 0.8208 to 1.000 | 0.0009 | >0.4471 | 90 | 59.58% to 99.49% | 90 | 59.58% to 99.49% | 0.95 | 0.8622 to 1.000 | 0.0007 | >1.192 | 80 | 49.02% to 96.45% | 80 | 49.02% to 96.45% |
| 4-HNE | 1 | 1.000 to 1.000 | 0.0002 | >8.293 | 100 | 72.25% to 100.0% | 100 | 72.25% to 100.0% | 1 | 1.000 to 1.000 | 0.0002 | >54.87 | 100 | 72.25% to 100.0% | 100 | 72.25% to 100.0% |
Abbreviations: 3-NT: 3-nitrotyrosine; 4-HNE: 4-hydroxynonenal; AA: ascorbic acid; AGE: advanced glycation end products; AUC: area under the curve; CAT: catalase; CI: confidence interval; GPx: glutathione peroxidase; GSH: reduced glutathione; GR: glutathione reductase; HOMA-IR: homeostatic model assessment for insulin resistance; PC: protein carbonyls; Px: peroxidase; ROC: receiver operating characteristic; SOD: superoxide dismutase; UA: uric acid.