Table 1.
Baseline sample characteristics across TSAT categories
| Characteristics | TSAT (%) | All | |||||
|---|---|---|---|---|---|---|---|
| ≤15 | 16–20 | 21–25 | 26–35 | 36–45 | ≥46 | ||
| N patients (row %) | 926 (18) | 1067 (21) | 1178 (23) | 1408 (27) | 428 (8) | 138 (3) | 5145 |
| Age, yr | 71±13 | 69±13 | 70±13 | 69±14 | 68±14 | 65±16 | 69±13 |
| % male | 53 | 56 | 58 | 64 | 69 | 62 | 59 |
| % Black | 6 | 6 | 4 | 5 | 6 | 5 | 5 |
| BMI, kg/m2 | 30±7 | 29±6 | 29±6 | 28±6 | 28±5 | 27±5 | 29±6 |
| Comorbidities (%) | |||||||
| Diabetes | 56 | 50 | 46 | 38 | 36 | 27 | 45 |
| Hypertension | 89 | 89 | 90 | 88 | 86 | 81 | 88 |
| Coronary artery disease | 33 | 32 | 29 | 24 | 23 | 24 | 28 |
| HF | 21 | 17 | 13 | 12 | 11 | 9 | 15 |
| Cerebrovascular disease | 13 | 12 | 11 | 10 | 8 | 8 | 11 |
| Peripheral vascular disease | 22 | 21 | 19 | 19 | 16 | 12 | 20 |
| Other cardiovascular disease | 31 | 25 | 25 | 23 | 20 | 17 | 25 |
| GI bleeding in past year | 3 | 1 | 1 | 1 | 1 | 0 | 1 |
| Lung disease | 13 | 11 | 9 | 8 | 7 | 10 | 10 |
| Cancer | 18 | 17 | 18 | 18 | 19 | 18 | 18 |
| Ulcers/gangrene of extremity | 2 | 2 | 3 | 2 | 2 | 0 | 2 |
| Neurologic disease | 3 | 3 | 3 | 4 | 4 | 4 | 3 |
| Psychiatric disorder | 9 | 10 | 8 | 7 | 8 | 8 | 8 |
| Prescriptions | |||||||
| ESA, % | 16 | 12 | 11 | 13 | 13 | 26 | 13 |
| Iron, IV or oral, % | 32 | 24 | 18 | 15 | 15 | 15 | 21 |
| Labs | |||||||
| TSAT, % | 12±3 | 18±1 | 23±1 | 29±3 | 39±3 | 55±12 | 24±10 |
| Ferritin, ng/ml | 122±160 | 160±178 | 189±177 | 235±219 | 257±221 | 444±502 | 196±214 |
| Hgb, g/dl | 11.5±1.8 | 12.1±1.7 | 12.3±1.8 | 12.6±1.8 | 12.8±1.9 | 12.4±2.1 | 12.3±1.8 |
| eGFR, ml/min per 1.73m2 | 27±10 | 28±10 | 28±11 | 29±11 | 29±12 | 30±12 | 28±11 |
| Albuminuria (%) | |||||||
| A1 (normal) | 28 | 29 | 28 | 28 | 28 | 30 | 28 |
| A2 (high) | 34 | 33 | 33 | 32 | 32 | 34 | 33 |
| A3 (very high) | 28 | 28 | 30 | 30 | 29 | 25 | 29 |
| A3 (nephrotic) | 10 | 10 | 9 | 10 | 11 | 11 | 10 |
| Serum albumin, g/dl | 3.9±0.5 | 4.0±0.5 | 4.0±0.4 | 4.0±0.5 | 4.0±0.5 | 4.0±0.5 | 4.0±0.5 |
| White blood cells, 109/L | 7.7±2.4 | 7.3±2.0 | 7.2±1.9 | 6.9±2.0 | 6.8±1.9 | 6.8±2.5 | 7.2±2.1 |
Results reported as % or mean±SD. Albuminuria categories: A1: <30 mg/g creatinine, A2: 30–300 mg/g creatinine, A3 (very high): >300–2000 mg/g creatinine, and A3 (nephrotic): >2000 mg/g creatinine.