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Study design and workflow summary. Analytical workflow for GWAS for C3 and C4 levels in the eMERGE network (primary analysis; top); refinement of genome-wide significant loci by conditional analysis, imputation, annotations, and single-locus PheWAS (secondary analyses; bottom right); and derivation of polygenic scores for C3 and C4 followed by a polygenic score–based PheWAS (exploratory analyses; bottom left). QC, quality control.
